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Feature Papers represent the most advanced research with significant potential for high impact in the field. FeaturePapers are submitted upon individual invitation or recommendation by the scientific editors and undergo peer reviewprior to publication.
The Feature Paper can be either an original research article, a substantial novel research study that often involvesseveral techniques or approaches, or a comprehensive review paper with concise and precise updates on the latestprogress in the field that systematically reviews the most exciting advances in scientific literature. This type ofpaper provides an outlook on future directions of research or possible applications.
Abstract:The lungs are affected by illnesses including asthma, chronic obstructive pulmonary disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models for respiratory conditions will be essential for new drug development. The composition and structure of the lung extracellular matrix (ECM) plays a major role in the function of the lung tissue and cells. Lung-on-chip models have been developed to address some of the limitations of current two-dimensional in vitro models. In this review, we describe various ECM substitutes utilized for modeling the respiratory system. We explore the application of lung-on-chip models to the study of cigarette smoke and electronic cigarette vapor. We discuss the challenges and opportunities related to model characterization with an emphasis on in situ characterization methods, both established and emerging. We discuss how further advancements in the field, through the incorporation of interstitial cells and ECM, have the potential to provide an effective tool for interrogating lung biology and disease, especially the mechanisms that involve the interstitial elements.Keywords: airway-on-a-chip; microfluidics; extracellular matrix; epithelial cells; endothelial cells; fibroblasts; remodeling; exposures; cigarette smoke; electronic cigarettes; analysis methods; bio-imaging
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" On a appris à développer sur du PHP et du Javascript. Nous avons aussi été formés en sécurité informatique, en gestion de GIT, ce qui, à l'époque, était tout récent. Ça a été une super rampe de lancement pour que je puisse aborder le métier du développement web"
Cette formation m'a apporté de nouvelles compétences comme Angular, Redis et MongoDb et m'a permis d'approfondir d'autres compétences comme le PHP orienté objet et Symfony. Les formateurs étaient expérimentés, passionnés et très intéressants.
Quelques jours après la fin de mon premier contrat, une entreprise m'a démarché pour un CDI. Puis une deuxième. Puis une troisième ! Il y a du travail dans ce secteur, on nous déroule le tapis rouge !
Dans ma promotion à la 3W Academy, j'étais la seule femme. Au début je me sentais intimidée par rapport aux autres. En intégration, notre formatrice était une femme : ça m'a rassuré dans ma légitimité à suivre cette formation. En plus, au fur et à mesure de l'avancement de la formation, j'ai commencé à faire partie des meilleurs donc j'ai retrouvé confiance en moi.
11 rue Louise Collet\nImmeuble Galice Mirabeau C\n13100 Aix en Provence\n","telephone":"0757176008"},{"name":"Grenoble","latlng":["45.19071","5.71883"],"adresse":"3 Rue colonel Denfert Rochereau\n38000 Grenoble\n","telephone":"0757176008"},{"name":"Lille","latlng":["50.70059","3.15729"],"adresse":"La Plaine Image\n99 A Boulevard Constantin Descat\n59200 Tourcoing\n","telephone":"0757076336"},{"name":"Marseille","latlng":["43.30932","5.38921"],"adresse":"37 rue Guibal\n13001 Marseille\n","telephone":"111555"},{"name":"Nantes","latlng":["47.20835","-1.53018"],"adresse":"44 rue de Strasbourg\n44000 NANTES\n","telephone":"111555"},{"name":"Paris","latlng":["48.89371","2.3543"],"adresse":"3W ACADEMY PARIS 18e : 56 rue Ren\u00e9 Clair 75018 Paris 3W ACADEMY PARIS 14e : 5 villa Lourcine 75014 paris\n","telephone":"0757076336"},{"name":"Rennes","latlng":["48.10562","-1.71821"],"adresse":"3W Academy\/Agence YesWeDev\n8 Quai Robinot de Saint-Cyr\n35000 Rennes\n","telephone":"0757076336"},{"name":"Strasbourg","latlng":["48.58392","7.74553"],"adresse":"8 rue du Faubourg de Saverne\n67 000 Strasbourg\n","telephone":"0679632021"},{"name":"Tunis","latlng":["36.84607","10.18944"],"adresse":"Imm. Louxor\n4B Av. Hedi KARRAY\nCentre Urbain Nord\nTUNIS\n","telephone":"54 62 01 15"}]');*/ Contact 2b1af7f3a8